Palabras claves: ACTIVIDAD FÍSICA/CALIDAD DE VIDA

Título: THE SURVEY OF THE EFFECT AEROBIC EXERCISES ON FUNCTION AND STRUCTURE OF HEART IN DIABETIC MALE RATS OF SPRAGUE DAWELY-ALBINO SPECIES.
Authors: Ali Khajeh landi, Amin Mohammadi Demih
Institution: Islamic Azad University Gachsaran Branch
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Fuente: Foro Mundial de Educación Física; II Cumbre Iberoamericana de Educación Física y Deporte Escolar; Simposio de Actividad Física y Calidad de Vida; Taller Internacional de  Deporte Escolar y Alto Rendimiento, 2010.

 

Abstract
The aim of this research is to study the effect of aerobic physical exercises on the performance and the heart structure of diabetic mice. Thus, the number of 48 male mice from Sprague Dawely race with the weight of 150 to 300 grams were bought and divided randomly in 4 groups each of which including 22 mice. These four groups consisted of the control group with physical exercise, the control group without physical exercise, diabetic group without physical exercise and diabetic group with physical exercise. These mice were affected by diabetes by the injection of strepotzotocin. The exercised protocol included three procedures: the first four weeks with the speed of 12 meters on a minute during the time of 10 minutes, the second four weeks with the speed of 22-23 meters on a minute during the time of 40 minutes and the final four weeks with the speed of 23-25 meters on a minute during the time of one hour. In this research the levels of blood sugar and the lipoproteins were measured by enzyme method and the blood pressure, thickness and cavity of heart by sensitive electrodes and echocardiography. The results showed that after 4 weeks of physical exercise, the levels of sugar, blood pressure and lipoproteins had not changed anyway but after 12 weeks of physical exercise, it was determined that the levels of blood sugar and blood pressure in diabetic group with physical exercise have decreased meaningfully (P


Introduction:
Those affected by diabetes are two or four times more than others in danger of the cardiovascular diseases. Also, the factors such as hypertension, lack of physical exercise, high LDL and VLDL cholesterol and the low level of HDL cholesterol all can be considered as dangerous factors (Mustafa et al.,2003). The physical exercises and losing the weight cause the prophylaxis of second type of diabetes, low blood pressure and help to decrease the heart attack, on the contrary gaining the weight and lack of physical exercise cause to increase the resistance against insulin (Berger et al.,2005). The hypertension has been considered as a dangerous factor for cardiovascular diseases (Nialy Ergen et al.,2005). The studies show that there is a direct and relatively high relation between hypertension and resistance against insulin.
Also, it was determined that the high level of LDL and the low level of HDL can have negative effect on the diabetes and heart performance (Berger et al2005; Bjorkman et al 2005; Mustafa et al 2005). The aim of this research is to study the effect of aerobic physical exercises on the performance and the heart structure of male diabetic mice.


Methodology:
In this research 88 male mice from albino Sprague Dawely with the weight of 150 to 300 grams were chosen. These animals were divided randomly in four groups of control without physical exercise (22 mice), control with physical exercise (22 mice), diabetic without physical exercise (22 mice) and diabetic with physical exercise (22 mice). These groups were kept individually in four different cages. Their room was preserved in a dark-bright cycle (12 to 12 hours). The mice were affected by diabetes by the injection of strepotzotocin. The aerobic physical exercise program continued during 12 weeks. Before starting the physical exercises, the mice were acclimatized by putting those three days in a cyclic line during the time of 20 minutes (twice a day). The exercised protocol included three procedures: the first four weeks with the speed of 12 meters on a minute during the time of 10 minute uring the time of 40 minutes and the final four weeks with the speed of 23-25 meters s, the second four weeks with the speed of 22-23 meters on a minute d on a minute during the time of one hour. In this research the levels of blood sugar and the lipoproteins were measured by enzyme method and the blood pressure, thickness and cavity of heart by sensitive electrodes and echocardiography.


Results:
The results showed that after 4 weeks of physical exercise, the level of sugar, blood pressure and lipoproteins had not changed anyway but after 12 weeks of physical exercise, it was determined that the levels of blood sugar and blood pressure have decreased meaningfully (P


Discussion:
The aerobic physical exercises in the diabetic mice cause low blood sugar and low blood pressure and these changes have usually meaningful relation with each other. In this research, 12 weeks with aerobic physical exercise on treadmill lost the weight of mice up to 4/8 percent while the weights of those without any mobility do not change during this period. It may conclude that the aerobic program with losing the weight can lead to increase the sensitivity to insulin (because of low blood sugar) and ameliorate cardiovascular system performance (according to low blood pressure and an increase in thickness and cavity of ventricle). Anyway, more researches are necessary to attain a final result in this field.


Reference:
1.Berger,M,et al.Pharmacokinetices of Subcutaneously injected insulin:effects of exercise.Diabetes,28(Suppl.1)2005.


2.Bjorkman,O,et al.Influence of hypoglucagonemia on splanchnic glucose output during leg exercise in man . Clin.physiol.1:43,2005.


3.Mustafa Gul,et al.Endurance training and Glutathione dependent antioxidant in heart of the diabetec rats.j of sports science & med.(2003)2,52-61.


4.Nialy Ergen,et al.The effect of aerobic exercise on skeletal muscle Metabolism,in diabetic rats.j of sports science & med.(2005)4,742-481.